Dental Essential Oil Studies Nausea and Vomiting

Evaluation of Oral Ginger Efficacy against Postoperative Nausea and Vomiting: A Randomized, Double – Blinded Clinical Trial

Akram Sadat Montazeri  1 Azam Hamidzadeh  2 Mehdi Raei  3 Malihe Mohammadiun  4 Azam Sadat Montazeri  5 Reza Mirshahi  6 Hosein Rohani  7
  • Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, IR Iran.
  • 2 School of Nursing & Midwifery, Shahroud University of Medical Sciences, Shahroud, IR Iran.
  • 3 Clinical Research Development Center, Qom University of Medical Sciences, Qom, IR Iran.
  • 4 School of Civil and Architectural Engineering, Shahrood University of Technology, Shahrood, IR Iran.
  • 5 School of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran.
  • 6 School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
  • 7 School of Health, Isfahan University of Medical Sciences, Isfahan, IR Iran.

PMID: 24693389

PMCID: PMC3955504

DOI: 10.5812/ircmj.12268


Background: Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures.

Objectives: The aim of this study was to determine the effect of ginger on intensity of nausea and vomiting after surgical procedures.

Patients and methods: This study was a randomized, double blinded, clinical trial. 160 eligible patients were randomly assigned into experimental or placebo groups. The experimental group received 4 capsules containing 250 mg ginger and placebo group received 4 placebo capsules 1 hour before surgery. The severity of nausea and vomiting was measured at 2, 4, 6 hours post operation using visual analogue scale and a structured questionnaire. The data were analyzed by independent t – test, Mann-Whitney U test, chi -square and GEE using SPSS 16 and STATA version 11.

Results: Mean nausea score at 2 hours post operation was significantly lower in the experimental group (P= 0.04). Mean nausea score at 4 and 6 hours post operation was lower in the experimental group; however, there was no significant difference between the groups at any time post operation. The frequencies of nausea in the experimental group at 2 and 6 hours post operation were lower than that in the placebo group, however, at 2 hours post operation, it was borderline significant (P = 0.05) There was no significant differences between two group in the intensity of vomiting at any time.

Conclusions: Use of ginger was effective at decreasing postoperative nausea. Ginger could be used as a safe antiemetic drug at post operation.

Keywords: Ginger; Nausea; Vomiting.

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